On November 16, 2025, several thousand demonstrators organized by Generation Z took to the streets of Mexico City to protest against crime and corruption. The protest escalated into violent confrontations with police outside the National Palace, where demonstrators reportedly used stones, fireworks, sticks, and chains against law enforcement. According to the Associated Press, the clashes resulted in 120 injuries, including 100 police officers, and led to the arrest of 20 individuals, with another 20 cited for administrative violations.

The protests were fueled by public outrage over government inaction and security failures, particularly following the assassination of Uruapan Mayor Carlos Manzo on November 1, 2025. Demonstrators expressed their frustrations with the current administration's handling of cartel violence, chanting slogans such as "Out, Morena" and accusing the government of complicity in the mayor's death. The mayor had previously voiced concerns about his safety in light of the rising violence.

Support for the protest extended beyond youth activists, with older individuals, including supporters of opposition parties, joining the movement. Participants highlighted the urgent need for improved security and healthcare funding, citing the pervasive insecurity affecting various sectors, including healthcare professionals.

In response to the protests, Mexico City Security Secretary Pablo Vázquez reported the injuries and arrests, while President Claudia Sheinbaum suggested that right-wing parties were attempting to co-opt the youth-led movement through social media manipulation. Some influencers distanced themselves from the protests, while notable figures such as former President Vicente Fox and billionaire Ricardo Salinas Pliego expressed their support for the demonstrators.